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Our data claim that active you, 25D signaling enriched Aire+ mTECs and enhanced the colocalization with the transcribing factor Vdr. The partial overlap between binding sites of the two proteins is consistent with the pleiotropic actions of both substances and shows that they may work together functionally. you, 25D increased the expression of Aire mRNA and improved the number of Aire+ cells in thymic pieces, and activated Aire-dependent COMPRESA TRA mRNAs in sorted TEC populations. 1, 25D treatment also increased Vdr colocalization with Éter in mTECs, cTECs, and thymocytes.
We revealed that digestive tract epithelial VDR regulates autophagy through their interaction with all the protein ATG16L1 and that decreased intestinal VDR expression correlates with dysbiosis in a colitis model. Current administration of the microbe product butyrate increases intestinal tract epithelial VDR expression and restores microbial homeostasis. This can be a first demonstration that VDR impacts the intestinal tract microbiome through its interaction with ATG16L1 and autophagy. We propose that intestinal epithelial VDR is a main regulator of intestinal homeostasis and that modulation of this radio could be an effective therapeutic technique to treat inflammatory bowel disease.